Plant milk Plant Bacillus grx03 : The “new nemesis” of uric acid

Dear readers, today we’re excited to share a groundbreaking discovery in the field of health: Lactobacillus plantarum. grx03 , a plant that may become uric acid The “new nemesis” probiotic.

Uric acid, health of Invisible Killer

Uric acid, a term that may sound somewhat unfamiliar, is actually a metabolic waste product in our bodies. Under normal circumstances, uric acid is excreted by the kidneys; however, when its production exceeds excretion, it can lead to hyperuricemia. Prolonged hyperuricemia is a major risk factor for conditions such as gout and kidney stones.

Currently, “high uric acid” “It has become the ‘fourth high’ following ‘hyperglycemia,’ ‘hypertension,’ and ‘hyperlipidemia.’ Hyperuricemia (” HUA ) is the second most common metabolic disease, after diabetes. According to publicly available data, the prevalence of hyperuricemia and gout worldwide has been increasing year by year, with projections indicating that from… 2016 year's 7.4 Increased by hundreds of millions to 2030 year's 14.2 Hundreds of millions of people. The number of cases in China is also increasing year by year, and it is estimated that… 2030 In the year, the number of cases will reach 2.4 Hundreds of millions of people; at present, our country has nearly… 2 Hundreds of millions of people are suffering from hyperuricemia and gout.

Source: “2021 China White Paper on Trends in Hyperuricemia and Gout”

Directions for Addressing Hyperuricemia

Currently, there are two main classes of urate-lowering drugs: agents that inhibit uric acid production (such as allopurinol) and agents that promote uric acid excretion (such as benzbromarone).

However, the drug’s adverse effects are also quite pronounced, which limits its clinical application; therefore, we need safer and more effective alternative therapies.

Uric acid is primarily excreted by the kidneys, while approximately… 25% Uric acid is excreted via the gastrointestinal tract. Various segments of the intestine harbor transport proteins that facilitate uric acid elimination, and certain microbial communities can also produce xanthine dehydrogenase, an enzyme capable of degrading uric acid.

These studies all demonstrate that the gut microbiota has become a subject of investigation. HUA A novel therapeutic target in the pathogenesis, employing microbial ecological preparations to… HUA Targeted therapies are also receiving increasing attention.

Research indicates that probiotic supplementation can effectively prevent the accumulation of uric acid. The addition of probiotics increases the abundance of Bifidobacteria and Lactobacilli, thereby… HUA The resulting gut microbiota dysbiosis is restored, thereby reducing serum uric acid levels and… LPS Horizontal, while simultaneously rising XO The activity of.

Plant milk Plant Bacillus grx03 The discovery of

The good news is, 2020 In [year], Haoyue, in collaboration with Professor Gu Ruixia’s team at Yangzhou University, identified a unique strain of Lactobacillus plantarum from its proprietary lactic acid bacteria germplasm repository. —— grx03 This strain not only significantly lowers uric acid levels but also originates from the population of Bama, a longevity village in Guangxi, and exhibits high safety and promising application prospects.

Certificate of Invention for Lactobacillus plantarum GRX03

grx03 The uniqueness of

Plant milk Plant Bacillus grx03 It has attracted considerable attention because it possesses the following notable characteristics:

① Powerful uric acid–lowering efficacy: grx03 It can in vitro. 100% It degrades guanosine and inosine—both precursors of uric acid—thereby effectively reducing uric acid production.

② Inhibition of xanthine oxidase activity: Xanthine oxidase is a key enzyme in the production of uric acid. grx03 The fermentation supernatant can significantly inhibit the activity of this enzyme. The inhibition rate reaches 94%， Further reduce uric acid production.

Broad application prospects

Based on these characteristics, Lactobacillus plantarum grx03 Its application prospects in the food industry are extremely broad. It can be used to develop fermented dairy products or lactic‑acid‑bacteria–based solid beverages that lower uric acid levels, offering a safe and effective dietary option for patients with hyperuricemia.

Compared with conventional drug therapy, the use of Lactobacillus plantarum grx03 Its products offer advantages such as the absence of drug-related adverse reactions and the lack of strict dietary restrictions, resulting in higher patient compliance.

Conclusion

Lactobacillus plantarum grx03 This discovery offers us a completely new approach to lowering uric acid levels. Not only does it effectively reduce uric acid, but it also enhances patients’ quality of life. As research progresses, there is good reason to believe that this probiotic will play an even more significant role in the health sector. Let us wait and see, looking forward to further insights into Lactobacillus plantarum. grx03 Good news!